Insulin secretion and sensitivity after simultaneous pancreas-kidney transplantation estimated by continuous infusion of glucose with model assessment

Background. Monitoring of insulin secretion and sensitivity after pancreas transplantation remains a practical problem. Methods. We introduced the simple structural model, continuous infusion of glucose with model assessment (CIGMA), to obtain insulin secretion and insu lin sensitivity estimations after 35 successful simultaneous pancreas-kidne y transplantations. Eighteen non diabetic kidney transplant recipients were used as control group. Results. The baseline characteristics were equal between the two groups exc ept for higher fasting insulin levels in the pancreas transplant group. Aft er the l-hr CIGMA glucose load, the pancreas transplant group reached a mea n+/-SD blood glucose of 8.2+/-1.7 mmol/L compared with 7.3+/-1.0 mmol/L in the control group (P=0.05). Concurrent stimulated insulin and C-peptide lev els were 48+/-28 mU/L and 2.3+/-0.9 nmol/L in the pancreas transplant group compared with 36+/-21 mU/L and 2.9+/-1.1 nmol/L in the control group (P=0. 1 and P=0.03, respectively). Both the CIGMA estimation for secretion as wel l as the CIGMA estimation for sensitivity were lower in pancreas transplant group (P=0.003 and P=0.01, respectively). Mean+/-SE coefficients of variat ion for the model estimations were 15+/-4% for secretion and 17+/-6% for se nsitivity. Conclusions. We conclude that CIGMA can be used clinically to evaluate carb ohydrate metabolism in pancreas-kidney transplant recipients. These patient s have a reduction in insulin secretory capacity and evidence of more insul in resistance than non-diabetic kidney transplant recipients.