Surveillance for hepatocellular carcinoma: compliance and results according to the aetiology of cirrhosis in a cohort of 141 patients

Surveillance for early detection of hepatocarcinoma (HCC) in patients with cirrhosis is widely accepted. In a cohort of 141 patients with cirrhosis co llected during the year 1995, we conducted a surveillance program by perfor ming liver ultrasonography and blood alpha-foetoprotein measurement every 6 months. The median followup was 34 months. This study addressed to two que stions: the compliance to the surveillance schedule according to the aetiol ogy of cirrhosis and the results in terms of emergence of HCC and outcome. Aetiology of cirrhosis was alcohol-induced in 86 (61%), HCV-related in 30 ( 21%) and from other origins in 25 (18%). Compliance to the program schedule was good in patients with HCV-related cirrhosis (29/30 - 97%) and patients with cirrhosis of "other origins" (20/25-80%) but was poor in patients wit h alcoholic cirrhosis (45/86- 52%). The lack of compliance was significantl y linked to the failure to achieve alcohol abstinence. During follow-up, 6 HCC lesions were observed in 6 male patients with media n age of 68 years. All 6 HCC were single nodule, less than 4 cm and accessi ble to percutaneous acetic acid injection. Nevertheless, the outcome was di sappointing, four patients dying 3-15 months later (median: 8 months), two of them with extensive HCC. One of the two patients still alive developed e xtensive HCC, 36 months after percutaneous acetic acid injection.