Feline immunodeficiency virus clade C mucosal transmission and disease courses

The transmissibility and pathogenicity of a clade C feline immunodeficiency virus (FIV-C) was examined via the oral-nasal, vaginal, or rectal mucosa, FIV-C was transmissible by all three mucosal routes. Vaginal transmission w as most efficient (100%), oral exposure resulted in a 80% infection rate, a nd rectal transmission was least effective (44%). In contrast to previous i ntravenous passage studies, a broader range of host-virus relationships was observed after mucosal exposure. Three categories of FIV-C infection were defined: (1) rapidly progressive infection marked by high virus burdens and rapid CD4(+) cell depletion (43% of vaginally exposed animals); (2) conven tional (typical) infection featuring slowly progressive CD4(+) cell decline (61% of all exposed animals); and (3) regressive (transient) infection mar ked by low and then barely detectable virus burdens and no CD4(+) cell alte rations (22% of rectally inoculated cats). These disease courses appear to have parallels in mucosal HIV and SIV infections, emphasizing the importanc e of the virus-mucosa interface in lentiviral pathogenesis.