Breakpoint within the nucleolus organizer region resulting in a reciprocaltranslocation t(4;14)(q21;p12)

Authors
Grabowski, M Fauth, C Wirtz, A Speicher, MR
Citation
M. Grabowski et al., Breakpoint within the nucleolus organizer region resulting in a reciprocaltranslocation t(4;14)(q21;p12), AM J MED G, 92(4), 2000, pp. 264-268
Citations number
25
Categorie Soggetti
Molecular Biology & Genetics
Journal title
AMERICAN JOURNAL OF MEDICAL GENETICS
ISSN journal
01487299 → ACNP
Volume
92
Issue
4
Year of publication
2000
Pages
264 - 268
Database
ISI
SICI code
0148-7299(20000605)92:4<264:BWTNOR>2.0.ZU;2-H
Abstract
Reciprocal translocations involving a break in the nucleolus organizer regi on (NOR) are rare. A balanced translocation in a mot-her and her fetus with breakpoints in the NOR at 14p12 and on the long arm of a chromosome 4 at b and 4q21 is described. The rearrangement was characterized by Ag-NOR staini ng, multiplex fluorescence in situ hybridization (M-FISH), and FISH with rD NA probes. This and other cases with breakpoints within NORs are discussed. Am. J. Med. Genet. 92:264-268, 2000. (C) 2000 Wiley-Liss, Inc.