The onset time of rocuronium is slowed by esmolol and accelerated by ephedrine

Citation
P. Szmuk et al., The onset time of rocuronium is slowed by esmolol and accelerated by ephedrine, ANESTH ANAL, 90(5), 2000, pp. 1217-1219
Citations number
15
Categorie Soggetti
Aneshtesia & Intensive Care","Medical Research Diagnosis & Treatment
Journal title
ANESTHESIA AND ANALGESIA
ISSN journal
00032999 → ACNP
Volume
90
Issue
5
Year of publication
2000
Pages
1217 - 1219
Database
ISI
SICI code
0003-2999(200005)90:5<1217:TOTORI>2.0.ZU;2-W
Abstract
Administration of ephedrine prior to rocuronium decreases the onset time of neuromuscular blockade from rocuronium by 26%. This effect was attributed to a increased cardiac output. If so, beta adrenergic-blocking drugs, which decrease cardiac output, should prolong the onset time of rocuronium. In a double-blind study, 60 patients were randomly assigned to three groups (n = 20) to receive either 70 mu g.kg(-1) of ephedrine, 0.5 mg.kg(-1) esmolol or placebo, 30 s before induction of anesthesia. Onset time of rocuronium w as defined as the time from the end of its injection to disappearance of al l four twitches of the train-of-four. The onset time of rocuronium was sign ificantly shorter after ephedrine (22%) and longer after esmolol (26%), as compared to placebo. No differences were observed among the three groups wi th regard to heart rate, systolic, diastolic or mean blood pressure. We con cluded that a dose of 0.5 mg.kg(-1) of esmolol significantly prolongs the o nset time of rocuronium with minimal hemodynamic changes.