Gastric lavage for liquid poisons

Study objective: This study was conducted to determine whether gastric lava ge reduces the absorption of ingested liquids. Methods: The study design was a randomized controlled human volunteer cross over study in 10 subjects. On 2 separate occasions 2 weeks apart, the volun teers ingested a solution of 4.0 g of acetaminophen in 60 mL of water. Eigh t blood specimens were obtained over the initial 8 hours for determination of serum acetaminophen concentrations, which were used to calculate routine pharmacokinetic parameters. One hour after 1 drug ingestion, gastric lavag e was performed through a 34-F orogastric tube. Serum acetaminophen concent rations were measured by high-performance liquid chromatography and a 2-tai led t test was used for statistical analysis. Results: The mean values for area under the concentration curve (+/-SD) for the control and gastric lavage groups were 195+/-31 and 154+/-52 mg/L.hour , respectively (P<.05). The mean reduction in acetaminophen bioavailability because of gastric lavage was 20%+/-28% (95% confidence interval 3 to 37). Conclusion: In this experimental model for the ingestion of liquids, gastri c lavage at 1 hour resulted in a significant decrease in the mean serum bio availability of acetaminophen. Nonetheless, this treatment effect is unlike ly to be of clinical value because of its modest extent, unreliable perform ance, and the availability of a more effective, less risky alternative, act ivated charcoal.