G. Kunig et al., Benzodiazepine receptor binding in Huntington's disease: [C-11]flumazenil uptake measured using positron emission tomography, ANN NEUROL, 47(5), 2000, pp. 644-648
We used positron emission tomography and [C-11]flumazenil to analyze the be
nzodiazepine receptor binding in symptomatic and asymptomatic carriers of t
he Huntington's disease gene. We found an inverse relationship between [C-1
1] flumazenil and [C-11]raclopride binding in the putamen of symptomatic pa
tients, and interpret this result as GABA receptor upregulation.