Serum elastase activity is elevated in migraine

Citation
C. Tzourio et al., Serum elastase activity is elevated in migraine, ANN NEUROL, 47(5), 2000, pp. 648-651
Citations number
19
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
ANNALS OF NEUROLOGY
ISSN journal
03645134 → ACNP
Volume
47
Issue
5
Year of publication
2000
Pages
648 - 651
Database
ISI
SICI code
0364-5134(200005)47:5<648:SEAIEI>2.0.ZU;2-#
Abstract
Migraine has been associated with diseases considered to be related to extr acellular matrix disorders-in particular, cervical artery dissection. In th is population-based study, we found a highly significant association betwee n migraine and the activity of serum elastase, a metalloendopeptidase degra ding specific elastin-type amino acid sequences. Such enzymes are involved in matrix degradation. This association was seen in both sexes and was stro nger for migraine with aura. These findings could help in che understanding of why patients with migraine are at higher risk of stroke. Further study is needed to establish whether extracellular matrix abnormalities play a br oader role in the pathophysiology of migraine.