Synthesis of 4,6-dichloro-3-[(1-N-arylaminocarbonyl)-hydrazono]-1,3-dihydro-indole-2-one as a potential NMDA receptor glycine site antagonist

Authors
Hwang, KJ Lee, TS
Citation
Kj. Hwang et Ts. Lee, Synthesis of 4,6-dichloro-3-[(1-N-arylaminocarbonyl)-hydrazono]-1,3-dihydro-indole-2-one as a potential NMDA receptor glycine site antagonist, ARCH PH RES, 23(2), 2000, pp. 112-115
Citations number
20
Categorie Soggetti
Pharmacology & Toxicology
Journal title
ARCHIVES OF PHARMACAL RESEARCH
ISSN journal
02536269 → ACNP
Volume
23
Issue
2
Year of publication
2000
Pages
112 - 115
Database
ISI
SICI code
0253-6269(200004)23:2<112:SO4>2.0.ZU;2-O
Abstract
A synthetic procedure for the preparation of indole-2,3-dione derivatives 6 as a potential NMDA receptor glycine site antagonist with improved pharmac ological profile compared with 2-carboxyindole derivative 5, starting from readily available 3,5-dichloroaniline (7), is described.