Citation
A. Barcenilla et al., Effect of nicorandil upon different guinea-pig and rat isolated organ preparations in vitro, ARZNEI-FOR, 50(4), 2000, pp. E341-E344
Citations number
18
Categorie Soggetti
Pharmacology & Toxicology
Journal title
ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
ISSN journal
00044172
→ ACNP
Volume
50
Issue
4
Year of publication
2000
Pages
E341 - E344
Database
ISI
SICI code
0004-4172(200004)50:4<E341:EONUDG>2.0.ZU;2-R
Abstract
A study of the effect of nicorandil (N-2-(hydroxyethyl)nicotinamide nitrate
, CAS 65141-46-0), a potassium channel and guanylatecyclase activator, upon
preparations of rat vas deferens and uterus, and guinea pig ileum was perf
ormed. Nicorandil does not modify rat isolated vas deferens responses to no
radrenaline (norepinephrine) and potassium. The drug exerts a noncompetitiv
e antagonist effect upon rat isolated uterus response to serotonin, histami
ne, oxytocin, and, at high concentrations, inhibits guinea-pig isolated ile
um responses to acetylcholine, histamine, 4-aminopyridine and potassium.