M. Nivsarkar, Improvement in circulating superoxide dismutase bevels: Role of nonsteroidal anti-inflammatory drugs in rheumatoid arthritis, BIOC BIOP R, 270(3), 2000, pp. 714-716
Citations number
19
Categorie Soggetti
Biochemistry & Biophysics
Journal title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Superoxide anion radical plays a significant role in inflammation, like rhe
umatoid arthritis. Superoxide dismutase enzyme known to dismutate superoxid
e anion radical does not play any significant role in this multisystem dise
ase. This paper reports that very low levels of circulating superoxide dism
utase levels are observed in patients with rheumatoid arthritis and these l
evels significantly improve with NSAID therapy. The possible mechanism of t
he action is discussed. (C) 2000 Academic Press.