Earliest pages of bioinformatics

This review is a brief outline of the chronology and essence of early event s in bioinformatics, covering the period from 1869 (discovery of DNA by Mie scher) to 1980-1981 (beginning of massive sequencing). For the purpose of t his review, bioinformatics is understood as a chapter of molecular biology dealing with the amino acid and nucleotide sequences and with the informati on they carry. Contact: edward.trifonov@weizmann.ac.il.