Resolution and synthesis of optically active alcohols with immobilized water-soluble proteins from green pea, soybean and buckwheat as new bio-catalysts
H. Nagaoka et H. Kayahara, Resolution and synthesis of optically active alcohols with immobilized water-soluble proteins from green pea, soybean and buckwheat as new bio-catalysts, BIOS BIOT B, 64(4), 2000, pp. 781-784
Kinetic resolution of racemic alcohols, (+/-)-1-(4-substituted phenyl)ethan
ol and (+/-)-1-(2-naphthyl)ethanol, was done with immobilized green pea, so
ybean, or buckwheat proteins. The resolution was done stereoselectively by
oxidizing only one enantiomer of a racemic alcohol to leave an optically ac
tive alcohol with a high purity. In addition, each protein could be reused
consecutively at least three times without any decrease of yield or optical
purity.