Citation
K. Yamamoto et al., Identification and characterization of a potent antibacterial agent, NH125against drug-resistant bacteria, BIOS BIOT B, 64(4), 2000, pp. 919-923
Citations number
18
Categorie Soggetti
Agricultural Chemistry","Biochemistry & Biophysics
Journal title
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
ISSN journal
09168451
→ ACNP
Volume
64
Issue
4
Year of publication
2000
Pages
919 - 923
Database
ISI
SICI code
0916-8451(200004)64:4<919:IACOAP>2.0.ZU;2-U
Abstract
New imidazole compounds were synthesized to develop a novel and effective a
ntibacterial agent (1-benzyl-3-cetyl-2-methylimidazolium iodide, NH125). In
vitro experiments demonstrated that NH125 effectively inhibited a number o
f different histidine protein kinases, Furthermore, oxacillin-resistant Sta
phylococcus aureus (ORSA), vancomycin-resistant Enterococcus faecalis (VRE)
, penicillin-resistant Streptococcus pneumoniae (PRS), and other Gram-posit
ive and Gram-negative bacteria were found to be very sensitive to NH125.