Effects of cholinergic deafferentation upon the expression of the alpha 2 subunit of the nicotinic acetylcholine receptors in the chick lateral spiriform nucleus

Authors
Torrao, AS Ferro, ES Lindstrom, JM Britto, LRG
Citation
As. Torrao et al., Effects of cholinergic deafferentation upon the expression of the alpha 2 subunit of the nicotinic acetylcholine receptors in the chick lateral spiriform nucleus, BRAIN RES, 863(1-2), 2000, pp. 249-253
Citations number
30
Categorie Soggetti
Neurosciences & Behavoir
Journal title
BRAIN RESEARCH
ISSN journal
00068993 → ACNP
Volume
863
Issue
1-2
Year of publication
2000
Pages
249 - 253
Database
ISI
SICI code
0006-8993(20000428)863:1-2<249:EOCDUT>2.0.ZU;2-B
Abstract
Lesion, immunohistochemical, and immunoblotting methods were used to evalua te the effects of cholinergic deafferentation upon the expression of the al pha 2 subunit of the nicotinic acetylcholine receptors in the lateral spiri form nucleus (SpL) of the chick brain. The expression of the alpha 2 subuni t in the SpL showed biphasic changes after lesion of its cholinergic source (nucleus semilunaris), with an increase after 2 days postlesion and a decr ease after 3-7 days. Our results could represent a correlate of the phenome na of nicotinic receptor up- and down-regulation, induced by removal of the cholinergic input. (C) 2000 Elsevier Science B.V. All rights reserved.