MOLECULAR TYPING OF HLA CLASS-I AND CLASS-II ANTIGENS IN INDIAN KALA-AZAR PATIENTS

HLA has been shown to be associated with many diseases. To find out wh ether host genetic factors like the HLA are involved in susceptibility to kala-azar (visceral leishmaniasis) in India, we formulated an asso ciation study with genetically related controls. All samples were type d by PCR SSOP (sequence specific oligonucleotide probes) for HLA class I (A and B) and class II (DR) antigens. The test of association we us ed was the transmission disequilibrium test (TDT). No significant evid ence for association with any of the three HLA loci was obtained.