Sm. Andersen et al., Syntheses of sugar-related trihydroxyazepanes from simple carbohydrates and their activities as reversible glycosidase inhibitors, CARBOHY RES, 326(1), 2000, pp. 22-33
Five diastereomeric trideoxy-1,6-iminohexitols were synthesised, and their
inhibitory activities were determined against selected glycosidases. For co
mparison, 1,4,5-trideoxy-l,5-imino-D-lyxo-hexitol, the 4-deoxy derivative o
f 1-deoxymannojirimicin, was prepared by enzymatic isomerisation of 6-azido
-3,6-dideoxy-D-riho-hexose into the corresponding 2-ulose and subsequent hy
drogenation accompanied by intramolecular reductive amination. (C) 2000 Els
evier Science Ltd. All rights reserved.