W. Tworetzky et al., Balloon arterioplasty of recurrent coarctation after the modified Norwood procedure in infants, CATHET C IN, 50(1), 2000, pp. 54-58
Coarctation of Be reconstructed aorta after the modified Norwood procedure
for hypoplastic left heart syndrome is a relatively common occurrence that
can have significant adverse effects. From 1992-98, 65 infants with hypopla
stic left heart syndrome or variants thereof underwent a modified Norwood p
rocedure. Of the 50 survivors of Stage I palliation, 10 (20%) were subseque
ntly diagnosed with clinically significant obstruction of the aortic arch a
t a median age of 5.1 months. Eight of these patients underwent coarctation
balloon arterioplasty. All 8 patients underwent successful dilation of the
coarctation, with a decrease in the pressure gradient from 43 +/- 20 to 4
+/- 5 mmHg and an increase in aortic diameter at the site of obstruction fr
om 3.5 +/- 0.5 to 7.0 +/- 1.0 mm (both P < 0.001). There was also a signifi
cant increase in lower extremity systolic blood pressure. Although there wa
s no immediate increase in cardiac output after dilation in most patients,
ventricular function was improved in 3 patients within 24-48 hr of the proc
edure and in all but 2 at the most recent follow-up (median 2 years). Two p
atients developed bradycardia during wire placement that required cardiopul
monary resuscitation. Two others died suddenly during the follow-up period.
All surviving patients have undergone subsequent palliative procedures; no
ne have required repeat intervention for arch obstruction. We found a 20% i
ncidence of coarctation in survivors of the modified Norwood procedure. Bal
loon arterioplasty is effective in relieving this obstruction, and should b
e carried out promptly upon diagnosis to minimize its deleterious effects o
n ventricular function. Balloon dilation, however, should be considered a h
igh-risk procedure in these fragile infants, and special attention must be
given to cardiovascular support. (C) 2000 Wiley-Liss, Inc.