Remote effects of acute ischemic stroke: A xenon CT cerebral blood flow study

Objective: The purpose of this study was to verify transhemispheric diaschi sis in the early hours after an ischemic event. Methods: XeCT cerebral bloo d flow (CBF) studies within 8 h of stroke were studied in 23 patients. Mean CBF was evaluated in the ischemic area, contralateral hemisphere and ipsil ateral cerebellum. Results: A severe CBF reduction was found in the ischemi c area (mean 9 +/- 3 ml/100 g/min). The mean CBF in the unaffected hemisphe re (33 +/- 10 ml/100 g/min) was 35% less compared to the normal mean value. CBF was decreased in the cerebellum ipsilateral to the stroke (mean 31 +/- 12 ml/100 g/min) suggesting a blood flow depression of the whole brain. Co nclusions: During the initial hours of cerebral ischemia, the asymptomatic hemisphere demonstrated CBF depression that was part of the global flow red uction. Copyright (C) 2000 S. Karger AG, Basel.