CFTA, a new efficient agent for determination of absolute configurations of chiral secondary alcohols

Authors
Takahashi, T Fukuishima, A Tanaka, Y Takeuchi, Y Kabuto, K Kabuto, C
Citation
T. Takahashi et al., CFTA, a new efficient agent for determination of absolute configurations of chiral secondary alcohols, CHEM COMMUN, (9), 2000, pp. 787-788
Citations number
17
Categorie Soggetti
Chemistry
Journal title
CHEMICAL COMMUNICATIONS
ISSN journal
13597345 → ACNP
Issue
9
Year of publication
2000
Pages
787 - 788
Database
ISI
SICI code
1359-7345(2000):9<787:CANEAF>2.0.ZU;2-U
Abstract
The CFTA method using alpha-cyano-alpha-fluoro-p-tolylacetic acid (CFTA) ca n be reliable in assigning absolute configurations of chiral secondary alco hols based on both H-1 and F-19 NMR spectroscopy, and the most stable and m ost predominant conformer of the CFTA esters that can explain the H-1 and F -19 NMR data were supported by X-ray analysis and ab initio calculations.