Oxepinamides A-C and fumiquinazolines H-I: Bioactive metabolites from a marine isolate of a fungus of the genus Acremonium

Three new oxepin-containing natural products (1-3) and two new fumiquinazol ine metabolites (4-5) have been isolated from organic extracts of the cultu re broth and mycelia of an Acremonium sp., a fungus obtained from the surfa ce of the Caribbean tunicate Ectcinascidia turbinata. The structures of the five compounds were determined through extensive analysis of 1D- and 2D-NM R data, and mass spectrometry. Compound 1 exhibited good anti-inflammatory activity in a topical RTX-induced mouse ear edema assay. Compounds 4 and 5 exhibited weak antifungal activity toward Candida albicans in a broth micro dilution assay.