Ap. Mansur et al., Angiotensin-converting enzyme and apolipoproteins genes polymorphism in coronary artery disease, CLIN CARD, 23(5), 2000, pp. 335-340
Background: Association between angiotensin-converting enzyme (ACE) as well
as apolipoprotein (apo) AI, B, and E polymorphisms and dyslipidemia and co
ronary artery disease (CAD) is controversial.
Hypothesis: This study assessed the distribution of ACE insertion/deletion,
apo AI A/G mutation, apo B signal peptide insertion/deletion, apo B XbaI r
estriction fragment length, and apo E polymorphisms in 388 nondiabetic pati
ents.
Methods: The study population included 112 patients with stable CAD, 139 pa
tients with acute myocardial infarction (AMI), and 137 age-matched control
subjects.
Results: Univariate analysis showed higher prevalence of XbaI X+/X+ genotyp
e in patients with CAD (p = 0.02). Angiotensin-converting enzyme and apo po
lymorphisms were not associated with Lipid levels or severity of CAD. When
all genotypes known to be related to CAD, such as ACE DD, apo Al GG, apo B
del/del, and XbaI X+X+, and Ecl allele of apo E, were pooled, again no sign
ificant differences among groups were seen. Multivariate regression analysi
s disclosed traditional risk factors and elevated levels of apo B for men a
nd reduced levels of apo AI for women as independent variables for CAD.
Conclusions: In addition to traditional coronary risk factors, apo B and AI
could be considered predictors of CAD. No association between either form
of CAD and polymorphisms was noted.