Growth in use of statins after trials is not targeted to most appropriate patients

Objective: To determine whether growth in the use of lipid-lowering drugs a fter publication of studies in the primary and secondary prevention of coro nary heart disease is in the population in which benefit was established, p articularly middle-aged men. Methods: We performed a series of pharmacoepidemiologic surveys of communit y prescribing in Ireland over 4 years. Results: Nationally, the use of lipid-lowering drugs (92% statins) increase d approximately fourfold from 1994 to 1998, In the Eastern Health Board reg ion, the number of monthly recipients increased from 447 in April 1994 to 3 530 in March 1998, Although use increased steadily after publication of Sca ndinavian Simvastatin Survival Study (4S) and West of Scotland Coronary Pre vention Study (WOSCOPS) in 1994 and 1995, respectively, this occurred to a greater extent in women, However, after the Cholesterol and Recurrent Event s (CARE) study in 1996 and subsequent recommendations that targeted statin use, particularly in men from 35 to 69 years old, there was a relatively gr eater increase in that population but, at 2.3%, it was well short of the ta rget population of 5.8%, More women than men older than 65 years are receiv ing statins. The 10-mg dosage (a fourth or half that used in studies) is th e most frequently dispensed. Conclusion: The use of statins, although rising rapidly is below targets an d was initially not directed at the population likely to benefit most or in the recommended dosage. Consequently, the benefits projected from clinical trials may not be seen in clinical practice.