Tec family kinases in lymphocyte signaling and function

Authors
Schaeffer, EM Schwartzberg, PL
Citation
Em. Schaeffer et Pl. Schwartzberg, Tec family kinases in lymphocyte signaling and function, CURR OP IM, 12(3), 2000, pp. 282-288
Citations number
65
Categorie Soggetti
Immunology
Journal title
CURRENT OPINION IN IMMUNOLOGY
ISSN journal
09527915 → ACNP
Volume
12
Issue
3
Year of publication
2000
Pages
282 - 288
Database
ISI
SICI code
0952-7915(200006)12:3<282:TFKILS>2.0.ZU;2-D
Abstract
The Tec kinases are required for full Ca2+ mobilization in lymphocytes. Rec ent data suggest that this process occurs via a multiprotein complex that i ncludes LAT and SLP-76 in T cells and BLNK/SLP-65 in B cells. Mutational an alyses have revealed critical roles for Tec kinases in lymphocyte developme nt and function.