Regulation of T cell function by NK cell receptors for classical MHC classI molecules

Authors
Ugolini, S Vivier, E
Citation
S. Ugolini et E. Vivier, Regulation of T cell function by NK cell receptors for classical MHC classI molecules, CURR OP IM, 12(3), 2000, pp. 295-300
Citations number
67
Categorie Soggetti
Immunology
Journal title
CURRENT OPINION IN IMMUNOLOGY
ISSN journal
09527915 → ACNP
Volume
12
Issue
3
Year of publication
2000
Pages
295 - 300
Database
ISI
SICI code
0952-7915(200006)12:3<295:ROTCFB>2.0.ZU;2-B
Abstract
Inhibitory receptors for MHC class I molecules were initially characterised on NK cells. Human and mouse NK cell receptors (NKRs) are also expressed o n T cells, predominantly on a subset of memory-phenotype CD8(+) T cells. Th is review focuses on the precise determination of interactions between NKRs and MHC class I, as well as on the unexpected in vivo function of NKRs on T cells.