Lack of DNA-damaging activity of five non-nutritive sweeteners in the rat hepatocyte/DNA repair assay

Authors
Jeffrey, AM Williams, GM
Citation
Am. Jeffrey et Gm. Williams, Lack of DNA-damaging activity of five non-nutritive sweeteners in the rat hepatocyte/DNA repair assay, FOOD CHEM T, 38(4), 2000, pp. 335-338
Citations number
19
Categorie Soggetti
Food Science/Nutrition","Pharmacology & Toxicology
Journal title
FOOD AND CHEMICAL TOXICOLOGY
ISSN journal
02786915 → ACNP
Volume
38
Issue
4
Year of publication
2000
Pages
335 - 338
Database
ISI
SICI code
0278-6915(200004)38:4<335:LODAOF>2.0.ZU;2-W
Abstract
The non-nutritive sweeteners acesulfame-K, aspartame, cyclamate, saccharin and sucralose were tested for DNA damaging activity in the rat hepatocyte/D NA repair assay. Using hepatocytes from F344 and Sprague-Dawley male rats, all were inactive despite strong responses for the positive control, 2-amin o-fluorene, (C), 2000 Elsevier Science Lid. All rights reserved.