"IARC Group 2A carcinogens" reported in cigarette mainstream smoke

As a follow-up to an earlier study on IARC Group 1 compounds, further effor ts have buen made to evaluate the international literature on cigarette mai nstream smoke for reports on constituents classified as IARC "Group 2A: pro bably carcinogenic to humans" and IARC ''Group 2B: possibly carcinogenic to humans." IARC classifies 59 agents, mixtures and exposures as Group 2A. Of the overall list of 59, 50 represent chemical entities or complex mixtures (IARC, 1998), When only chemical entities,which have their origin from cig arette components (tobacco and paper) are considered, further searching of the international literature has revealed that nine chemical compounds of t he 50 Group 2A listings have been reported in cigarette mainstream smoke (T able 1), In micrograms/cigarette (mu g/cig), the ranges reported for each o f the nine compounds are as follows: formaldehyde (3.4-283); benzo[a]pyrene (B[a]P) (0.004-0.108); dibenz[a,h]anthracene (DB[a,h]A) (0.004-0.076); N-n itrosodiethylamine (DEN) (non-detectable-0.0076); benz[a]anthracene (B[a]A) (trace-0.08); N-nitrosodimethylamine (DMN) (non-detectable-0.7-1.62); acry lamide (1.1-2.34); 1,3-butadiene (16-77); and 2-amino-3-methyl-3H-imidazo[4 ,5-f]quinoline) (0.00026-0.00019). (C) 2000 Elsevier Science Ltd, Al rights reserved.