A t(2;19)(p13;p13.2) in a giant invasive cardiac lipoma from a patient with multiple lipomatosis

Cardiac lipomas occur infrequently but account for a significant portion of rare cardiac tumors. Common cutaneous lipomas have previously been associa ted with rearrangements of chromosome band 12q15, which often disrupt the h igh-mobility-group protein gene HMGIC. In this report, we describe the cyto genetic analysis of an unusual giant cardiac lipoma that exhibited myocardi al invasion in a patient with a history of multiple lipomatosis (cutaneous lipoma, lipomatous gynecomastia, lipomatous hypertrophy of the interatrial septum, and dyslipidemia). Cytogenetic studies of cells derived from the ca rdiac lipoma demonstrated no abnormalities of chromosome 12, but did reveal a t(2; 19)(p 13;p13.2). A liposarcoma-derived oncogene (p115-RhoGEF) previ ously mapped to chromosome 19 and the low-density lipoprotein receptor gene (LDLR) previously mapped to chromosome band 19p13 were evaluated to determ ine whether they were disrupted by this translocation. Fluorescence in situ hybridization analyses assigned p115-RhoGEF to chromosome 19 in bands q13. 2-q13.3 and mapped the LDLR to chromosome arm 19p in segment 13.2, but cent romeric to the t(2; 19) breakpoint. Thus, these genes are unlikely to be in volved in the t(2;19)(p 13;p 13.2). Further studies of the regions of chrom osomes 2 and 19 perturbed by the translocation in this unusual infiltrating cardiac lipoma will identify gene(s) that participate in adipocyte growth and differentiation and may provide insight into syndromes of multiple lipo matosis. Genes Chromosomes Cancer 28:133-137, 2000. (C) 2000 Wiley-Liss, In c.