Design and syntheses of 2-oxiranecarboxylate derivatives and their hypoglycemic activities

Authors
Jew, S Kim, E Je, S Zhao, LX Kim, H Park, W Ko, K Kim, W Kim, HJ Cheong, JH Lee, ES
Citation
S. Jew et al., Design and syntheses of 2-oxiranecarboxylate derivatives and their hypoglycemic activities, HETEROCYCLE, 52(3), 2000, pp. 1087
Citations number
14
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
HETEROCYCLES
ISSN journal
03855414 → ACNP
Volume
52
Issue
3
Year of publication
2000
Database
ISI
SICI code
0385-5414(20000301)52:3<1087:DASO2D>2.0.ZU;2-C
Abstract
A series of 2-oxiranecarboxylate derivatives were prepared as carnitine pal mitoyl transferase I (CPT-I) inhibitors for the development of new antidiab etic agents. The syntheses and biological activities were reported. The mos t promising derivative (13b) showed 2.5 times more hypoglycemic activity an d 2 times lower acute toxicity compared to Etomoxir ((3)).