W. Miwa et al., Regression of gastric mucosa-associated lymphoid tissue lymphoma with reduced telomerase activity after eradication of Helicobacter pylori, INTERN MED, 39(4), 2000, pp. 300-304
Recently, telomerase activity has been demonstrated in a large number of ma
lignant tumors whereas its activity is not detected in most normal somatic
cells suggesting its role in the immortalization process. Here we report th
e first investigation of telomerase activity in a case of gastric mucosa-as
sociated lymphoid tissue (MALT) lymphoma. Elevated telomerase activity was
detected in biopsy specimens of the lymphoma. After eradication of Helicoba
cter pylori, the level of telomerase activity returned to normal with histo
logical regression of the lymphoma. The telomerase activity was associated
with the disease activity of the gastric MALT lymphoma after eradication th
erapy in the present case.