Genetic changes in breast cancer detected by comparative genomic hybridisation

Breast cancer is characterised by a number of genetic aberrations. Our purp ose was to use comparative genomic hybridisation (CGH) to screen breast car cinomas for copy number changes: 44 ductal and 8 lobular carcinomas were st udied and a large number of genetic aberrations identified. Many of these s howed similarity to previous CGH results, however, a number of loci not pre viously shown to have undergone frequent change were identified. This inclu ded copy number gains affecting chromosomes 1p, 4q, 5q, 6q and 13q, Further more, we have identified 2 regions of copy number change, the gain on 5p an d deletion of 16q, which correlated with lobular carcinomas. Our results hi ghlight several areas of the genome that may be important in the molecular genetics of breast cancer. Int. J, Cancer 86:494-500, 2000, (C) 2000 Wiley- Liss, Inc.