HIV-1 co-infection in children hospitalised with tuberculosis in South Africa

SETTING: Hospitals associated with the Department of Paediatrics at the Uni versity of the Witwatersrand, Johannesburg, South Africa. OBJECTIVES: To define the prevalence of human immunodeficiency virus (HIV) co-infection and differences in clinical presentation between HIV-infected and noninfected hospitalised children with tuberculosis. DESIGN: Children were prospectively enrolled between August 1996 and Januar y 1997. RESULTS: Of 161 children enrolled, 42% were HIV-infected, including 67/137 with pulmonary tuberculosis (PTB) and 1/24 with extra-pulmonary disease (EP TB). Positive microscopy or bacteriology did not differ by HIV status for c hildren with either PTB or EPTB. Although age did not differ between HIV-in fected and non-infected children with PTB, non-HIV-infected children with E PTB were significantly older than those with PTB only (median age 32 months vs 14.5 months, P = 0.004). Chronic weight loss, malnutrition and the abse nce of BCG scarring were more common in HIV-infected children with PTB. HIV -infected children were also more likely to show cavitation (P = 0.001) and miliary TB (P = 0.01) on chest X-ray. Reactivity to tuberculin (greater th an or equal to 5 mm and greater than or equal to 10 mm in HIV-infected and noninfected children, respectively) was significantly lower in HIV-infected children, as were CD4+ lymphocyte levels. The mortality rate during the st udy was 13.4% in HIV-infected children compared with 1.5% in non-HIV-infect ed children (P = 0.03). CONCLUSIONS: There is a high prevalence of HIV coinfection in children with TB. Progressive PTB and death are more common in HIV-infected children. Tu berculin skin testing is of limited use in screening for TB in HIV-infected children even when using a cut-point of greater than or equal to 5 mm.