Investigation of linkage and association - Issues on study design

Authors
Citation
H. Bickeboller, Investigation of linkage and association - Issues on study design, INT STAT R, 68(1), 2000, pp. 75-81
Citations number
22
Categorie Soggetti
Mathematics
Journal title
INTERNATIONAL STATISTICAL REVIEW
ISSN journal
03067734 → ACNP
Volume
68
Issue
1
Year of publication
2000
Pages
75 - 81
Database
ISI
SICI code
0306-7734(200004)68:1<75:IOLAA->2.0.ZU;2-G
Abstract
For the identification and description of susceptibility genes for complex diseases using genetic markers there are two basic strategies: genome scans or the investigation of candidate genes. The designs can be quite differen t for the two approaches and decide, more than in general epidemiology, the methods that can be applied subsequently. Study design, recruitment and sa mple size are discussed further in the context of the Transmission/Disequil ibrium Test, a family-based simultaneous test for linkage and the context o f the association.