New biologically active rubiginones from Streptomyces sp.

Citation
C. Puder et al., New biologically active rubiginones from Streptomyces sp., J ANTIBIOT, 53(4), 2000, pp. 329-336
Citations number
25
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF ANTIBIOTICS
ISSN journal
00218820 → ACNP
Volume
53
Issue
4
Year of publication
2000
Pages
329 - 336
Database
ISI
SICI code
0021-8820(200004)53:4<329:NBARFS>2.0.ZU;2-I
Abstract
Four new polyketides, named rubiginone D-2 (2), 4-O-acetyl-rubiginone D-2 ( 3), rubiginone H (6) and rubiginone I (7) were isolated from the cultures o f Streptomyces sp. (strain Go N1/5). Their structures were established by a detailed spectroscopic analysis. The absolute configuration of 3 was deter mined by derivatization with chiral acids (Helmchen's method). The rubigino nes inhibit the growth of some Gram-positive bacteria and are cytostaticall y active against different tumor cell lines.