Synthesis and biological evaluation of novel tricyclic carbapenems (trinems)

Authors
Kanno, O Shimoji, Y Ohya, S Kawamoto, I
Citation
O. Kanno et al., Synthesis and biological evaluation of novel tricyclic carbapenems (trinems), J ANTIBIOT, 53(4), 2000, pp. 404-414
Citations number
12
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF ANTIBIOTICS
ISSN journal
00218820 → ACNP
Volume
53
Issue
4
Year of publication
2000
Pages
404 - 414
Database
ISI
SICI code
0021-8820(200004)53:4<404:SABEON>2.0.ZU;2-X
Abstract
Synthesis of new tricyclic carbapenems (trinems) with a pyrrolidinyl moiety at the C-4 position of the tricyclic ring and their antimicrobial activiti es were studied. These trinems showed potent activities against Gram-positi ve bacteria including methicillin-resistant Staphylococcus aureus (MRSA). A mong them, (4R)-[(S)-pyrrolidin-3-ylthiomethyl]trinem (14a) exhibited good activity against MRSA in vitro and in vivo.