Enantioselective determination of drugs in body fluids by capillary electrophoresis

During the past decade, chiral capillary electrophoresis (CE) emerged as a promising, effective and economic approach for the enantioselective determi nation of drugs in body fluids, hair and microsomal preparations. This revi ew discusses the principles and important aspects of CE-based chiral bioass ays, provides a survey of the assays developed and presents an overview of the key achievements encountered. Applications discussed encompass the phar macokinetics of drug enantiomers, the elucidation of the stereoselectivity of drug metabolism and bioanalysis of drug enantiomers of toxicological and forensic interest. (C) 2000 Elsevier Science B.V. All rights reserved.