Enantioselective determination by capillary electrophoresis with cyclodextrins as chiral selectors

This review surveys the separation of enantiomers by capillary electrophore sis using cyclodextrins as chiral selector. Cyclodextrins or their derivati ves have been widely employed for the direct chiral resolution of a wide nu mber of enantiomers, mainly of pharmaceutical interest, selected examples a re reported in the tables. For method optimisation, several parameters infl uencing the enantioresolution, e.g., cyclodextrin type and concentration, b uffer pH and composition, presence of organic solvents or complexing additi ves in the buffer were considered and discussed. Finally, selected applicat ions to real samples such as pharmaceutical formulations, biological and me dical samples are also discussed. (C) 2000 Elsevier Science BN. All rights reserved.