Enantiomeric separations by use of polymeric surfactant electrokinetic chromatography

This review surveys the enantiomeric separation of drugs by electrokinetic chromatography using polymeric chiral surfactant pseudostationary phases. T hese phases have recently been shown to provide better mass transfer and in creased rigidity and stability than regular micelles in micellar capillary electrophoresis. Characterization of the polymeric chiral surfactants is pr esented. Solution interactions of the pseudostationary phases via thermodyn amics and fluorescence probe studies are evaluated. Also, case studies of e nantiomeric separation of drugs using a single amino acid surfactant and th e synergistic effect of the addition of gamma-cyclodextrin to the buffer is discussed. The use of dipeptide surfactants for chiral drug separations is described as well. (C) 2000 Elsevier Science B.V. All rights reserved.