Chiral glycosidic surfactants for enantiomeric separation in capillary electrophoresis

Several glycosidic surfactants (GSs) have been shown useful in the separati on of enantiomers by capillary electrophoresis. The virtue of GSs is that t hey can be used as (i) neutral chiral additives in the running electrolyte for the enantioseparation of charged chiral solutes by capillary zone elect rophoresis, (ii) as in situ charged micelles for the enantioseparation of n eutral and charged chiral solutes by micellar electrokinetic capillary chro matography (MECC), (iii) as anionic chiral surfactants in the MECC mode upo n covalently attaching negatively charged groups to their sugar head groups , and (iv) as neutral and anionic chiral surfactants mixed with achiral mic elles (e.g., sodium dodecyl sulfate) for MECC of enantiomers. This review a rticle is to provide a comprehensive description of GSs in the chiral separ ation of various enantiomers over a wide range of operating conditions. (C) 2000 Elsevier Science B.V. All rights reserved.