Application of ligand-exchange capillary electrophorersis to the chiral separation of alpha-hydroxy acids and beta-blockers

The application of the principle of ligand-exchange capillary electrophores is to two substance classes is described. As chiral selector N-(2-hydroxyoc tyl)-L-4-hydroxyproline-copper(II) complex was used. This principle was app lied to the chiral separation of alpha-hydroxy acids and drugs containing a mino alcohol structure such as beta-blockers. The enantioselectivity was fo und to be strongly dependent on pH corresponding to the optimal conditions for complex formation for each structure class. (C) 2000 Elsevier Science B .V. All rights reserved.