Predictive values of waist circumference for dyslipidemia, type 2 diabetesand hypertension in overweight White, Black, and Hispanic American adults

Waist circumferences (WC) greater than or equal to 102 cm for men and great er than or equal to 88 cm for women have been proposed by an expert panel a s cut-points for identifying increased risk for the development of obesity comorbidities for most adults. The aim of this investigation was to examine the predictive values of these WC cut-points for hypercholesterolemia. low concentration of high (HDL-C), and high concentration of low (LDL-C) densi ty lipoprotein cholesterol, hypertriglyceridemia, type 2 diabetes, and hype rtension in overweight American adults. Data from NHANES III were utilized for the analysis. Predictive abilities were determined by calculating sensi tivity, specificity, positive (PV+) and negative (PV-) predictive values in overweight subjects with BMI 25-29.9 km(2). Sensitivity of WC cut-point wa s stronger for high LDL-C compared to other risk factors with the highest v alues recorded in the 40-59 and 60-69 year age groups in men and women, res pectively. PV+ of WC cut-points for dyslipidemia, type 2 diabetes, and hype rtension were low in men compared to women. PV+ tended to increase with age , from 19-39, 40-59 to 60-90 year age groups in Whites, Blacks, and Hispani c men. In men, the highest PV+ were recorded for hypertriglyceridemia in th e 60-90 years old groups, with values of 71.6%, 52.5%, and 43.3% in Whites, Blacks, and Hispanics, respectively. The CVD risk factor associated with t he highest PV+ in women was diabetes with values of 97.2% in Whites and 88. 9% in Blacks, and hypertriglyceridemia with a value of 93.5% in the 17-39 y ear age group in Hispanics. Among Black men 40-59 years of age, only 32% of a population of overweight hypertensives were detected by the WC cut-point s, and among Black women, 40-59 years of age, only 54% were detected. Given the low sensitivity of these cut-points for detecting hypertension, one of the major co-morbidities of obesity, these cut-points failed to provide ad equate evidence for the use of WC in determining or evaluating patients as to co-morbid states. We recommend further studies to determine a set of spe cific cut-points associated with increased risk of CVD in different populat ion groups. (C) 2000 Elsevier Science Inc. All rights reserved.