In several species, including primates, stimulation studies indicate that t
he infralimbic cortex, the most caudal part of the ventromedial prefrontal
cortex, functions as a visceral motor region. In addition, recent positron
emission tomography studies implicate the subgenual region in depression an
d mania. To determine the subcortical projections of this region in primate
s, injections of Phaseolus vulgaris leukoagglutinin, biotinylated dextran a
mine, or rhodamine-labeled dextran amine were placed in area 25 in three mo
nkeys. In contrast to the efferents from area 25 previously described in th
e rat, there were no projections to autonomic effector regions, such as the
nucleus of the solitary tract, magnocellular neurosecretory cell groups in
the hypothalamus, ventrolateral medulla, or intermediolateral column of th
e spinal cord. However, projections were shown to a number of structures wi
th probable roles in autonomic function and direct connections to some of t
he abovementioned autonomic effector regions, including bed nucleus of the
stria terminalis, perifornical and anterior hypothalamus, periaqueductal gr
ay, and lateral parabrachial nucleus. In addition, there were projections t
o several forebrain structures that receive projections from other componen
ts of the medial prefrontal network including the medial part of the caudat
e nucleus, lateral septum. midline and mediodorsal thalamic nuclei, the lat
eral parvocellular part of the basal accessory amygdaloid nucleus, and the
magnocellular part of the basal amygdaloid. None of the injections resulted
in labeling in the medulla. These connections support the idea of a role f
or cortical area 25 in emotional and autonomic responses, albeit less direc
t than that described in rodents. (C) 2000 Wiley-Liss, Inc.