The expression of products of oncogens c-erbB2 and EGFR and proliferating antigens Ki67 and PCNA in primary invasive ductal cancer of female breast

The aim of the study was to examine the consecutive series of primary ducta l invasive tumours and find out: a) the expression of some biological cellu lar parameters as proliferating antigens Ki67 and PCNA and products of gene EGFR, erbB2; b) correlation between the levels of expression of those fact ors and classical prognostic factors, such as diameter of tumour, status of axillary lymph nodes, status of steroids receptors, the degree of histolog ical differentiation. We found that: I. The presence of the expression of o ncoproteins c-erbB2 and EGFR, high index IP PCNA, Ki67 and low levels of st eroids receptors correlates with high histological malignancy (Bloom III de grees); 2. The lack of expression of oncoproteins c-erbB2, EGFR and low ind ex IP PCNA, Ki67 correlates with high levels of steroids receptors; 3. The estimation of high levels of index IP PCNA, IP Ki67 can be helpful for sepa rate tumours of high proliferating activity; 4. The expression of oncoprote in c-erbB2 and EGFR does not correlate with the diameter of tumour as well as with the involvement of axillary lymph nodes. It seems that the estimation of proliferating antigens together with the ex pression of oncoproteins might have greater prognostic value than the estim ation of one of these factors.