p24/ING1-ALT1 and p47/ING1-ALT2, distinct alternative transcripts of p33/ING1

Authors
Saito, A Furukawa, T Fukushige, S Koyama, S Hoshi, M Hayashi, Y Horii, A
Citation
A. Saito et al., p24/ING1-ALT1 and p47/ING1-ALT2, distinct alternative transcripts of p33/ING1, J HUM GENET, 45(3), 2000, pp. 177-181
Citations number
10
Categorie Soggetti
Molecular Biology & Genetics
Journal title
JOURNAL OF HUMAN GENETICS
ISSN journal
14345161 → ACNP
Volume
45
Issue
3
Year of publication
2000
Pages
177 - 181
Database
ISI
SICI code
1434-5161(2000)45:3<177:PAPDAT>2.0.ZU;2-V
Abstract
p33/ING1s (the growth inhibitor ING1 and candidate tumor suppressor ING1) a re key players in the suppressive pathways for human tumorigenesis. We anal yzed their complete transcripts, primary structures, and expression. The re sults led us to discover two novel and related alternatively spliced transc ripts encoding p24/ING1-ALT1 and p47/ING1-ALT2. They share C-terminal resid ues with the candidate tumor suppressors p33/ING1. The candidate tumor supp ressors p33/ING1 and p24/ING1-ALT1 were coexpressed in a variety of fetal a nd adult human tissues, but p47/ING1-ALT2 was minimally expressed.