Jr. Petrella et al., ASSESSMENT OF WHOLE-BRAIN VASODILATORY CAPACITY WITH ACETAZOLAMIDE CHALLENGE AT 1.5 T USING DYNAMIC CONTRAST IMAGING WITH FREQUENCY-SHIFTEDBURST, American journal of neuroradiology, 18(6), 1997, pp. 1153-1161
Citations number
34
Categorie Soggetti
Clinical Neurology","Radiology,Nuclear Medicine & Medical Imaging
PURPOSE: To determine whether whole-brain acetazolamide-induced change
s in regional cerebral blood volume (rCBV) can be assessed on a conven
tional gradient 1.5-T MR system using 3-D dynamic susceptibility contr
ast-enhanced MR imaging, METHODS: A 3-D frequency-shifted (FS) burst t
echnique was used to assess the intravascular first pass of contrast a
gent, Changes in rCBV were calculated in 40 volunteers before and afte
r acetazolamide (n = 30) or saline (n = 10) injection using customized
analysis software on an independent workstation. A single-section gra
dient-echo technique with better spatial resolution was used in one ad
ditional volunteer to examine the effect of partial volume averaging o
n calculation of absolute rCBV, RESULTS: A statistically significant i
ncrease in rCBV (gray matter = 23%, white matter = 32.5%) was noted af
ter acetazolamide compared with saline. Baseline fractional CBVs were
22% +/- 3% for gray matter and 12% +/- 2% for white matter. Partial vo
lume averaging was probably responsible for a systematic but linear ov
erestimation of absolute rCBV. CONCLUSION: Acetazolamide-induced chang
es in rCBV can be assessed using 3-D dynamic susceptibility contrast-e
nhanced MR imaging with FS-burst on a conventional gradient 1.5-T MR s
ystem. Values obtained with this technique overestimate absolute rCBV
but are systematically biased and can be used for intersubject and int
rasubject ratio comparisons.