Strategic options for antenatal screening for syphilis in the United Kingdom: a cost effectiveness analysis

Objective-Antenatal screening for syphilis is well established in the Unite d Kingdom. The prevalence of syphilis is now very low, prompting the questi on as to whether this screening programme is still necessary. This paper ai ms at identifying possible screening strategy options for the programme and comparing their effectiveness and cost effectiveness. Methods-The cost of the screening programme in the United Kingdom was estim ated. This was based on the cost of screening tests, treatment, and follow up of infected women and their infants. This information was obtained from laboratories, antenatal clinics, and genitourinary medicine clinics. Epidem iological data from a survey of women treated for syphilis in pregnancy wer e analysed to identify groups at increased risk of syphilis. Strategic opti ons for the screening programme were then identified. The effectiveness, nu mber needed to treat, and cost effectiveness of these options were compared . Results-Antenatal screening in the United Kingdom detected at least 40 preg nant women who need treatment for syphilis every year. This means that 18 6 02 women are screened for every woman detected who needs treatment for syph ilis. The marginal annual cost of this screening programme in the United Ki ngdom is pound 672 366. This is equivalent to 90p per woman screened, or po und 16 670 to detect one woman who needs treatment for syphilis. The screen ing programme could be targeted geographically at pregnant women in the Tha mes regions. This option has the potential to save pound 482 185. Other str ategic options are to target pregnant women in non-white ethnic groups, or those born outside the United Kingdom. These targeted options would each de tect between ne 70% and 77% of women needing treatment for syphilis. These options could potentially save pound 592 938 and pound 562 691 respectively . Conclusions-Targeting or stopping the screening programme would save relati vely little money. Although selectively screening groups by country of birt h or by ethnic group could detect at least 70% of cases, this would be poli tically and practically difficult. Targeting by region would also be effect ive, but would pose similar ethical and medicolegal problems. These facts a nd the changing international epidemiology of syphilis lead us to recommend that the current universal antenatal screening for syphilis should continu e.