Bioactive compounds from Combretum erythrophyllum

Authors
Schwikkard, S Zhou, BN Glass, TE Sharp, JL Mattern, MR Johnson, RK Kingston, DGI
Citation
S. Schwikkard et al., Bioactive compounds from Combretum erythrophyllum, J NAT PROD, 63(4), 2000, pp. 457-460
Citations number
15
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
63
Issue
4
Year of publication
2000
Pages
457 - 460
Database
ISI
SICI code
0163-3864(200004)63:4<457:BCFCE>2.0.ZU;2-Y
Abstract
A methanol extract of Combretum erythrophyllum showed inhibitory bioactivit ies in a yeast-based microtiter assay for DNA-damaging agents. Bioassay-gui ded fractionation of this extract yielded two known bioactive compounds, co mbretastatin A-1 and (-)-combretastatin, and two new bioactive glucosides, combretastatin A-1 2'-beta-D-glucoside (1) and combretastatin B-1 2'-beta-D -glucoside (2). The structures of the new compounds were assigned by H-1 an d C-13 NMR, DEFT, HMQC, and HMBC spectra.