Quadranosides I-V, new triterpene glucosides from the seeds of Combretum quadrangulare

Five new triterpene glucosides, quadranosides I-V (1-5), have been isolated from a MeOH extract of the seeds of Combretum quadrangulare, together with 13 known compounds. The structures of compounds 1-5 were elucidated on the basis of spectroscopic analysis. Among the new triterpene glucosides, thre e compounds (1, 2, 5) showed significant hepatoprotective effects against D -galactosamine (D-GalN)/tumor necrosis factor-alpha (TNF-alpha)-induced cel l death in primary cultured mouse hepatocytes.