Distinguishing illness severity from tic severity in children and adolescents with Tourette's disorder

Objective: To examine whether tic severity, comorbid disorders, or both are associated with illness morbidity in youths with Tourette's disorder (TD). Method: Subjects were 156 consecutively referred youths (aged 5-20 years) who met DSM-III-R criteria for Tourette's disorder at a major academic medi cal center. All subjects were evaluated with a clinical interview by a chil d and adolescent psychiatrist and an assessment battery that included the S chedule for Affective Disorders and Schizophrenia for School-Age Children-E pidemiologic version. Statistical analysis used chi(2) and multivariate log istic regression. Results: Nineteen (12%) of the 156 youths with TD require d psychiatric hospitalization. Current age, TD severity, TD duration, obses sive-compulsive disorder, psychosis, major depression, bipolar disorder, pa nic disorder, and overanxious disorder were significant univariate predicto rs of psychiatric hospitalization (p < .01]. While tic severity was margina lly significant as a predictor of psychiatric hospitalization (p < .05), ma jor depression (p < .016) and bipolar disorder (p < .001) were robust predi ctors of psychiatric hospitalization, even after statistical adjustment far collinearity and correction for all other variables assessed. Conclusion: The findings indicate that comorbid mood disorders are strongly associated with illness morbidity in youths with TD, highlighting the importance of at tention to comorbidity in patients with TD.