Pharmacogenetic prediction of clozapine response

We did association studies in multiple candidate genes to find the combinat ion of polymorphisms that give the best predictive value of response to clo zapine In schizophrenic patients. A combination of six polymorphisms in neu rotransmitter-receptor-related genes resulted in 76.7% success in the predi ction of clozapine response (p=0.0001) and a sensitivity of 95% (+/-0.04) f or satisfactory response. These results will form the basis for a simple te st to enhance the usefulness of clozapine in psychiatric treatment.